Essays Biochem. 2011

Essays Biochem. 2011-23
Functional, metal-based cross linkers for α-helix induction in short peptides, , 8416-8419 (2012).

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The plant hormone auxin plays critical roles in the control of plant growth and development.

Getting a grasp on domain III/IV responsible for Auxin Response Factor-IAA protein interactions. Specifically, we are focused on the interaction of two major protein families in the pathway, the Auxin Response Factors (ARFs; transcription factors) and the Aux/IAA repressors (Aux/IAAs).

Through homology modeling, crystal structure analysis and in vitro studies, we and others have identified potential domains and specific amino acids in the CTD that are essential for the interaction.

We have introduced single and multiple site-specific mutations of selected residues in ARFs, and are currently examining the in vivo effects of these mutations on growth, development and the transcriptional response to auxin, in transgenic Arabidopsis plants.

When auxin levels are elevated, the nuclear auxin receptor (an F-box protein that is part of a multisubunit ubiquitin ligase complex) binds auxin and associates with Aux/IAA repressors.

Lavenus J, Goh T, Guyomarc'h S, Hill K, Lucas M, Voß U, Kenobi K, Wilson MH, Farcot E, Hagen G, Guilfoyle TJ, Fukaki H, Laplaze L, Bennett MJ. Inference of the Arabidopsis lateral root gene regulatory network suggests a bifurcation mechanism that defines primordia flanking and central zones. Nanao MH, Vinos-Poyo T, Brunoud G, Thévenon E, Mazzoleni M, Mast D, Lainé S, Wang S, Hagen G, Li H, Guilfoyle TJ, Parcy F, Vernoux T, Dumas R. Structural basis for oligomerization of auxin transcriptional regulators. One current model of auxin signal transduction proposes that when auxin levels in a cell are low, the expression of auxin response genes is reduced due to the interaction of dominant Aux/IAA repressors with ARF activators bound to Aux REs of auxin response genes.

"The Shadow Scholar" became the most read article in the history of The Chronicle of Higher Education.

Although student cheating is nothing new, this article underscored the extent to which student cheating had become a business, in which students paid others to do their work, sometimes for an entire course.

Combined steric and electronic effects of positional substitution on dimethyl-bipyridine rhenium(I)tricarbonyl electrocatalysts for the reduction of CO 12013-12022 (2013).

Tezcan “Metal-Directed and Templated Assembly of Protein Superstructures and Cages”, in “Coordination Chemistry in Protein Cages”, Takafumi Ueno and Yoshi Watanabe (editors), Wiley & Sons (2013), [PDF] S.


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